Gene Polymorphism Analysis of LEPR (Leptin Receptor) in Ruminant Species of Sheep, Goat and Cattle Based on Gene Bank Database
DOI:
https://doi.org/10.29303/jitpi.v11i2.251Keywords:
LEPR Gene, Cattle, Goat, Sheep , SNPAbstract
Sheep have a morphology is closer to goat than cattle. The morphological similarities and differences between the three species are not always accompanied by phenotypic differences and similarities in their reproductive characteristics. Therefore, reproductive characteristics between the three need to be studied at the genetic level. The LEPR gene is a strong candidate for a gene regulating reproductive traits. This study aims to compare LEPR gene profiles between sheep, goats and cattle. The method used in this research is inductive descriptive statistical analysis. Profiling was carried out using the BLAST (local alignment) program in NCBI. The polymorphisms obtained were then analyzed for the type of mutation. Through local alignment, it is known that there are SNP changes and amino acid changes. Amino acid changes produce silent mutations, neutral mutations, and missense mutations in different proportions. Based on the overall research results, it can be concluded that the LEPR genes between the three species have different profiles. These differences can explain why sheep, goats and cows have different reproductive characteristics.
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